Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome
نویسندگان
چکیده
منابع مشابه
Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome
Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5)...
متن کاملMaternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters.
OBJECTIVE Subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy have been associated with an increased risk of gestational diabetes. We aimed to ascertain if these women have a worse metabolic phenotype than euthyroid pregnant women. DESIGN, SUBJECTS AND METHODS We recruited 956 healthy Caucasian women with singleton, non-diabetic pregnancies from routine antenatal clinics. D...
متن کاملMaternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function
BACKGROUND Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. OBJECTIVE To deter...
متن کاملPlacental microRNA Expression Is Not Altered by Maternal Obesity and Fetal Overgrowth
Objective The epigenetic mechanisms underlying fetal metabolic programming are poorly understood. We studied whether obesity is associated with alterations in placental miRNA expression. Study Design A cross-sectional study was performed, including (1) normal-weight women (BMI 20-24.9 kg/m2) and normal-birth-weight (BW) infants (2,700-3,500 g) (n = 20), (2) normal-weight and macrosomic infants ...
متن کاملPre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood.
OBJECTIVES Placental derived vasculogenic/angiogenic substances in maternal blood are dysregulated in pre-eclampsia. We hypothesized that CXCL12, a chemokine with vasculogenic actions, is amongst such molecules. STUDY DESIGN CXCL12, CXCL16, CXCR4, and CXCR6 immunolocalization in placental tissue was analyzed in pre-eclampsia (n=8) in comparison to controls (n=8). CXCL12, measured by ELISA in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0169223